Title of article
Enolate Conjugate Addition to Alkylidene Bis-Sulfoxides: Sphaeric Acid Synthesis and Absolute Configuration Determination
Author/Authors
Brebion، Franck نويسنده , , Goddard، Jean-Philippe نويسنده , , Gomez، Catherine نويسنده , , Fensterbank، Louis نويسنده , , Malacria، Max نويسنده ,
Pages
-712
From page
713
To page
0
Abstract
The first stereoselective synthesis of sphaeric acid is described. The key step of this synthesis is an efficient ester enolate conjugate addition onto alkylidene bissulfoxides with good to high diastereoselectivity. Formation of sphaeric acid allowed the determination of its absolute configuration as 2R,3R.
Keywords
enolate addition , alkylidene bis-sulfoxides , sphaeric acid , E/Z-enolate , succinic acid
Journal title
Astroparticle Physics
Record number
111071
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