2-Alkylidene-4-oxothiazolidine Vinyl Bromides: Versatile Precursors for C(5) Functionalization via Pyridine-Assisted Bromine Transfer

A series of structurally diverse vinyl bromides, derived from push-pull 2-alkylidene-4-oxothiazolidines, undergoes pyridine-assisted bromine transfer from the C=C bond to the C(5) position, enabling different C(5) functionalization. The type of the product depends on the C(5) substituent and, in some cases, the transformation is affected by the substituent at the C=C bond.