Title of article :
Chemoselective N-Alkylation of Di-N,O-protected Tyrosine through Specific Oxy-Anion Solvation by Non-Hydrogen Bonding Donor Solvents
Author/Authors :
Penso، Michele نويسنده , , Albanese، Domenico نويسنده , , Landini، Dario نويسنده , , Lupi، Vittoria نويسنده , , Scaletti، Davide نويسنده ,
Abstract :
N-(2-Nitro-benzenesulfonyl) activated l-tyrosine methyl ester has been directly N-alkylated under solid-liquid phase-transfer catalysis (SL-PTC) conditions and in a coordinating non-hydrogen bonding donor (non-HBD) solvent, which reduces through specific solvation the nucleophilicity of the oxy-anionic center of the N,Odianion formed by action of an anhydrous inorganic carbonate.
Keywords :
phase-transfer catalysis , amino acids , alkylations , chemoselectivity , solvent effects
Journal title :
Astroparticle Physics
