Ligand Tailoring: The First Modular Assembly of Atropisomeric Biarylbisphosphine Ligands

Strategies based on highly selective halogen-metal permutations have been devised and applied enabling the modular assembly of atropisomeric biaryl bisphosphines. After resolution on chiral column, the ligands were tested in benchmark hydrogenation reactions affording good to excellent enantioselectivity.