Rapid and Selective Synthesis of Substituted 1,2,5-Thiadiazolidine 1,1-Dioxides

The reaction of N,N-dimethylsulfamoyl aziridines with primary amines gives direct access to substituted 1,2,5-thiadiazol­idines in a regioselective manner. Furthermore, the product from ­reaction with 4-methoxybenzyl amine can be subsequently mani­pulated to give the alternative nitrogen substitution pattern in a ­ controlled fashion.