Title of article :
Synthesis of Enantiopure Prolines via exo-Stereoselective 1,3-Dipolar Cycloadditions to Acetone-Derived Chiral Stabilised Azomethine Ylides
Author/Authors :
Draffin، William N. نويسنده , , Harwood، Laurence M. نويسنده ,
Abstract :
The chiral stabilised azomethine ylide formed from condensation of the dimethyl acetal of acetone with (5S)-5-phenylmorpholinone undergoes stereoselective exocycloaddition reactions with a range of doubly and singly activated dipolarophiles when generated in the presence of excess MgBr2·OEt2. The cycloadducts can be degraded to yield enantiomerically pure proline derivatives.
Keywords :
Lewis acid , stereoselective cycloaddition , 5,5-disubstituted prolines , ketone-derived azomethine ylide
Journal title :
Astroparticle Physics
