Title of article :
A Facile Synthesis of an Oxazolo[5,4]pyrimidin-2-one and a Pyrimido[5,4][1,3]oxazin-2-one
Author/Authors :
Niculescu-Duvaz، Dan نويسنده , , Springer، Caroline J. نويسنده , , Dijkstra، Harmen P. نويسنده , , Gaulon، Catherine نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A facile synthesis is reported for the construction of the five- and six-membered fused carbamate rings of an oxazolo[5,4] pyrimidin-2-one and a pyrimido[5,4][1,3]oxazin-2-one, respectively. The method utilises a controlled two-step procedure in which a reactive p-nitrophenylcarbamate intermediate ring closes upon treatment with base, affording the bicyclic pyrimidinecarbamate scaffolds in good yields.
Keywords :
pyrimidines , cyclic carbamates , heterocyclic chemistry , ring-closing
