Metal-Halogen Exchange Using tri-n-Butyl Lithium Magnesate in the Diazine Series: Diazine 49

We report herein the ‘metal-halogen exchange’ reaction in the diazine series with lithium tri-n-tributylmagnesate. The ­reaction was performed with 2-iodopyrazine, 2-methylsulfanyl-4-iodopyrimidine and 3-iodo-6-phenylpyridazine. Benzophenone, ­ aldehydes and diphenylsulfur were used as electrophiles affording alcohols and phenylsulfanyl derivatives with satisfactory to good yields.