Author/Authors :
Ali ، F نويسنده epartment of Basic Science, Faculty of Dentistry, Sinai University, North of Sinai, Al-Arish, Egypt , , Bakry، S نويسنده Center for Genetic Engineering and Embryo Culture, Al Azhar University, Cairo, Egypt , , Hassan، A نويسنده Zoology Department, Al Azhar University, Cairo, Egypt , , El Bana، A نويسنده epartment of Basic Science, Faculty of Dentistry, Sinai University, North of Sinai, Al-Arish, Egypt , , El-Dean، US نويسنده Zoology Department, Al Azhar University, Cairo, Egypt ,
Abstract :
Injectable contraception has been available for over 50 years and is currently used by some 35 millionwomen
worldwide. Depo-Provera®; Depot-Medroxyprogesteroneacetate (DMPA) and Mesocept® are used as
contraceptive agents in Egypt. Possible contraceptive effects on embryos remain controversial. The aimof this study
was to assess the effects of the two injectable contraceptives on embryos of rats. Sixty pregnant rats(Sprague-Dawley) were assigned into ten groups, these animals were intramuscularly injected on the sixth day ofgestation
(GD6) with single dose of DMPA or Mesosept (Vehicle0; 2.7; 5.4; 0.99 and1.98 mg/rat). Animals were sacrificed
on day 15 or 19 of gestation and the embryos examined. Results showed that Both DMPA and Mesocept caused
embryonic toxicity manifested in malformations and in a reduction of the number of surviving embryos, increased
the mortality and resorption rate as well as causing a decrease in the embryonic crown rump (p < 0.05). In addition,
there was a widespread developmental malformation of the skeletal system. These findings shed more light on the
effects of DMPA and Mesocept, and support the claims that these hormonal contraceptive are embryo-toxic and
have teratogenic effect.
