Author/Authors :
Hosseinimehr، Seyed Jalal نويسنده Department of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran. , , Rostamnezad، Mostafa نويسنده Department of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Delete , , Ghafari-rad، Vahid نويسنده Department of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Research Center, Mazandaran University of Medical Sciences, Sari, Iran. ,
Abstract :
Background and Aim: Bleomycin (BLM) is an anti-cancer drug widely used in
the treatment of cancer. BLM causes several side effects related to DNA and
cellular damage. The aim of this study was investigated the effects of tea
polyphenol epicatechin on anti-proliferative effects induced by bleomycin in
human normal skin and human ovarian cancer cells.
Methods: Human ovarian cancer cell (SKOV-3) and human non-malignant
fibroblast cell (HFFF2) were treated with epicatechin at various concentrations
(10, 25 and 50 ?M) and BLM alone and with their combinations, further their
effects on cell viability were evaluated.
Results: The combined treatment of epicatechin with BLM enhanced significantly
inhibition of cell growth in comparison to BLM alone in cancer cell. Epicatechin
enhanced significantly cytotoxicity induced by BLM with 83% at dose 50 ?M,
while it was 92% in BLM-treated cells. Epicatechin was not showed any
cytotoxicity on HFFF2 cells.
Conclusion: Study suggests that epicatechin chemosensitize the ovarian cancer
cell to BLM-induced growth inhibition without any toxicity on normal cell.
