Author/Authors :
Sattari، Mandana نويسنده , , PeymaniMojaver، Ali نويسنده Department of Maxillo-facial Surgery, Dental School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , , Behnia، Hossein نويسنده Department of Maxillo-facial Surgery, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Kavand، Golnaz نويسنده Departments of Preventive and Community Dentistry, University of Iowa, College of Dentistry, Iowa, USA , , Darbandi-Tamijani، Hassan نويسنده Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran. Iran ,
Abstract :
Background and Aim: The cytokines have a major role in the inflammatory
response to surgery and trauma. They have local effects of mediating and
maintaining the inflammatory response to tissue injury, and also initiate some of
the systemic changes which occur. IL-6 is one of the above mentioned cytokines,
but it is not clear whether the duration of trauma or surgery has some effect on IL-
6 level, so the aim of this study was to investigate the relationship between plasma
levels IL-6 and duration of orthognathic surgery.
Methods: Twenty eight patients underwent orthognathic surgery were enrolled in
this study. Blood samples were collected one day before and 4 hours after surgery
for assessment the levels of plasma IL-6 which was measured by enzyme-linked
immunosorbent essay.
Results: We found a significant elevation of plasma IL-6 level at 4 hours after
surgery (P < 0.05). Moreover, the elevation of plasma IL-6 level was correlated
with the duration of surgery.
Conclusion: IL-6 is an important inflammatory mediator that its concentration is
increased with the duration of surgery.
