Title of article :
A theoretical study on activation of transcription factor modulated by intracellular Ca2+ oscillations Original Research Article
Author/Authors :
Chun-lian Zhu، نويسنده , , Xiang Yuan Zheng and Ser Tong Quek، نويسنده , , Ya Jia، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
7
From page :
49
To page :
55
Abstract :
This work presents both deterministic and stochastic models of genetic expression modulated by intracellular calcium (Ca2+) oscillations, based on macroscopic differential equations and chemical Langevin equations, respectively. In deterministic case, the oscillations of intracellular Ca2+ decrease the effective Ca2+ threshold for the activation of transcriptional activator (TF-A). The average activation of TF-A increases with the increase of the average amplitude of intracellular Ca2+ oscillations, but decreases with the increase of the period of intracellular Ca2+ oscillations, which are qualitatively consistent with the experimental results on the gene expression in lymphocytes. In stochastic case, it is found that a large internal fluctuation of the biochemical reaction can enhance gene expression efficiency specifically at a low level of external stimulations or at a small rate of TF-A dimer phosphorylation activated by Ca2+, which reduces the threshold of the average intracellular Ca2+ concentration for gene expression.
Keywords :
transcription factor , Kinetic model , intracellular calcium oscillation
Journal title :
Biophysical Chemistry
Serial Year :
2007
Journal title :
Biophysical Chemistry
Record number :
1119909
Link To Document :
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