Analysis of radiation effects using a combined cell cycle and multistage carcinogenesis model Original Research Article

To study radiation effects using a combined cell cycle and multistage clonal expansion model that includes processes of damage, repair, apoptosis, and mutation. The model includes endogenous and radiation induced damage causing progression of cells from normal, to damaged, to initiated, to initiated damage, to malignant status. We utilize complementary deterministic and stochastic versions of the model that share the same transition rates. The deterministic version is used to calibrate model rates for cell cycle progression, damage, checkpoint delay, repair, and apoptosis, and to implement tissue homeostasis. The stochastic version is used to predict the cancer hazard and survival.