Author/Authors :
Mohammadzade، Jahangir نويسنده Proteomics Research Center, Faculty of Para medical Sciences , , Amirrasouli، Houshang نويسنده Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University, MC, Tehran, , , Akbari، Mohammad Esmaeil نويسنده Cancer Research Center, shohada hospital , , Javanmard، Babak نويسنده , , Kazerouni، Faranak نويسنده Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University, MC, Tehran , , Namaki، Saeed نويسنده , , Rahimipour، Ali نويسنده Proteomics Research Center, Faculty of Para medical Sciences , , Tahbaz-lahafi، Behnoosh نويسنده Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Mahdavi، Meisam نويسنده ,
Abstract :
Perforin(p) is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory cytokines and stored in T lymphocyte , NK cells and NKT cells are released upon activation. Perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens , alloantigens and particularly different tumors.The purpose of this study was to determine perforin level in prostate cancer (P.Ca) and Benign Prostatic Hyperplasia (BPH). This study was performed on 59 patients consisting of 28 patients with P.Ca and 31 patients with BPH. Perforin and PSA levels were measured in cancer and BPH patients using ELISA method.
Mean Perforin value was significantly lower in P.Ca patients than in BPH patients ( p < 0.01) where as mean serum PSA level was significantly higher in the cancer patients in comparison to the BPH group (P < 0.01). Our finding indicate probability of problem in expression of cytotoxic molecule ,perforin in and around the tumor.
