Author/Authors :
Movafagh، Abolfazl نويسنده Medical Genetics Department, Shaheed Beheshti University of Medical Sciences , , Ghanati ، Kiandokht نويسنده Research Departmant of The International Branch of Shahid Beheshti University of Medical Sciences & Health Services , , Amani ، Davar نويسنده Department of Immunology, School of Medicine , , Mahdavi، Seyed Mohammad نويسنده Faculty of Paramedical Sciences, Proteomics Research Center , , Hashemi، Mehrdad نويسنده , , Zare Abdolahi، Davood نويسنده Department of Medical Genetics, Faculty of Medicine , , Darvish، Hossein نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Gholami، Milad نويسنده Gholami, Milad , HaghNejad، Leyla نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Mosammami، Sara نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Safari، Shamsi نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Darehgazani، Reyhaneh نويسنده Department of Medical Genetics, Faculty of Medicine , , Rahimi، Mahnoosh نويسنده Department of Medical Genetics, Faculty of Medicine , , Zamani، Mahdi نويسنده , , Ghandehari Motlagh، Mehdi نويسنده School of Dentistry, Pediatric Dentistry , , Safavi Naini، Nilofar نويسنده Department of Medical Genetics, Faculty of Medicine ,
Abstract :
Lectins first discovered more than 100 years ago in plants, they are now known to be present throughout nature. Phytohemagglutinin (PHA), the lectin extract from the red kidney bean (Phaseolus Vulgaris), contain potent, cell agglutinating and mitogenic activities. They play a role in biological recognition phenomena involving cells and proteins towards medical applications. The present article is a brief review of the history of lectin in nature. By reviewing the web-based search for all types of peer review articles published, was initiated using ISI web of Sciences and Medline / PubMed, and other pertinent references on websites about lectins. Here, we present a brief account of 100-plus years of lectin research and show how these proteins have become the focus of intense interest for biologists and in particular for the research and applications in medicine. Phytohemagglutinin, has been widely used for mitotic stimulation to human lymphocytes, cell arrest, or apoptosis, potential sources for developing novel pharmaceutical preparation and intensive interest for health care services, biologist and phytomedicine research can be considered.
