One-pot catalytic synthesis of higher aliphatic ketones Original Research Article

The catalytic synthesis of high molecular weight aliphatic ketones by reductive condensation of lower molecular weight ketones was achieved by using CO in the presence of a multifunctional catalyst containing copper dispersed on alumina. The useful combination of condensation, water gas shift and hydrogenation reactions in a one-pot reaction allowed high yields of methylisobutylketone from acetone.