Author/Authors :
Farhadmollashahi ، Leila نويسنده Assistant Professor, Dental Research Center, Department of Oral Medicine, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan-Iran. , , Nakhaie ، Alireza نويسنده Associate Professor, Department of Biochemistry, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan- Iran , , Honarmand، Marieh نويسنده Department of Oral Disease, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran Honarmand, Marieh , Arbabikalati ، Fateme نويسنده AssociateProfessor, Department of Oral Medicine, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan- Iran. , , Ghahari ، Payam نويسنده Specialist of Oral Medicine, Zahedan-Iran. ,
Abstract :
Introduction: The habit of smokeless tobacco chewing is one of the known risk factors for oral cancer among the residents of southeast of Iran. Most likely, the antioxidant defense system in dealing with free radicals induced paan and prevention of oral cancer is important. In this study, the activity of super oxide dismutase is compared in the saliva of paan consumers and
non-consumers.
Methods: In this study, Unstimulated saliva of 87 subjects (47 paan consumers and 40
non-consumers) who referred to the Oral Medicine Department of Dentistry School of Zahedan was collected. The activity of super oxide dismutase enzyme was measured by standard biochemical methods (Mc Cord and Fridovich) and the obtained data were analyzed by statistical software SPSS-15 through non-parametric Mann-Whitney test.
Results: The mean activity of super oxide dismutase was significantly higher in the paan consumers group (4.4±1.6 u/mg) compared to non-consumers (3.59±1.8 u/mg, p=0.027).
Conclusions: The results of this study demonstrate that consumption of paan leads to increased activity of salivary super oxide dismutase.
