Author/Authors :
Christophe Escudé، نويسنده , , Shahla Mohammadi، نويسنده , , Jian-Sheng Sun، نويسنده , , Chi Hung Nguyen، نويسنده , , Emile Bisagni، نويسنده , , Jean Liquier، نويسنده , , Eliane Taillandier، نويسنده , , Thérèse Garestier، نويسنده , , Claude Hélène، نويسنده ,
Abstract :
zIntroduction: Based on molecular modeling studies, a model has been proposed for intercalation of triple-helixspecific ligands (benzopyridoindole (BPI) derivatives) into triple helices, in which the intercalating compounds interact mainly with the Hoogsteen-paired strands of the triple helix. We set out to test this model experimentally using DNA duplexes capable of forming parallel Hoogsteen base-paired structures.
Results: We have investigated the possible formation of a parallel DNA structure involving Hoogsteen hydrogen bonds b
Keywords :
* parallel DNA , * triple helix , * Hoogsteen , * intercalation
