Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site Original Research Article

Comparison of the recently solved structure of HIV-1reverse transcriptase (RT)-DNA-dNTP ternary complex with the previously solved structure of RT-DNA binary complex suggests mechanisms by which the HIV-1 RT becomes resistant to nucleoside-analog inhibitors, drugs currently used in the treatment of AIDS.