Title of article
Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site Original Research Article
Author/Authors
Stefan G. Sarafianos، نويسنده , , Kalyan Dasi، نويسنده , , Jianping Dingi، نويسنده , , Paul L. Boyer، نويسنده , , Stephen H. Hughes، نويسنده , , Edward Arnold، نويسنده ,
Issue Information
ماهنامه با شماره پیاپی سال 1999
Pages
10
From page
137
To page
146
Abstract
Comparison of the recently solved structure of HIV-1reverse transcriptase (RT)-DNA-dNTP ternary complex with the previously solved structure of RT-DNA binary complex suggests mechanisms by which the HIV-1 RT becomes resistant to nucleoside-analog inhibitors, drugs currently used in the treatment of AIDS.
Journal title
Chemistry and Biology
Serial Year
1999
Journal title
Chemistry and Biology
Record number
1158129
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