Author/Authors :
Minnie M Wu، نويسنده , , Juan Llopis، نويسنده , , Stephen Adams، نويسنده , , J. Michael McCaffery، نويسنده , , Markku S. Kulomaa، نويسنده , , Terry E. Machen، نويسنده , , Hsiao-Ping H Moore، نويسنده , , Roger Y. Tsien، نويسنده ,
Abstract :
Abstract
Background: Mammalian organelles of the secretory pathway are of differing pH. The pH values form a decreasing gradient: the endoplasmic reticulum (ER) is nearly neutral, the Golgi is mildly acidic and the secretory granules are more acidic still (∼pH 5). The mechanisms that regulate pH in these organelles are still unknown.
Keywords :
* H+ leak , * Targeted fluorescence , * H+ pump , * Flubi-2
