Title of article
Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA
Author/Authors
Dwaine A. Braasch، نويسنده , , David R Corey، نويسنده ,
Issue Information
ماهنامه با شماره پیاپی سال 2001
Pages
7
From page
1
To page
7
Abstract
Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2′-oxygen and the 4′-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.
Keywords
Locked nucleic acid , RNA recognition , Gene expression control , DNA recognition
Journal title
Chemistry and Biology
Serial Year
2001
Journal title
Chemistry and Biology
Record number
1158333
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