Polychlorinated Biphenyls Inhibit Amyloid Fibril Formation

In this issue of Chemistry & Biology, Purkey et al. [] compare the binding of PCBs and hydroxylated PCBs (polychlorinated biphenyls) with the human serum protein transthyretin. Hydroxylated PCBs appear to bind with higher selectivity to transthyretin relative to other serum proteins and in so doing inhibit amyloid fibril formation.