Author/Authors :
OMIDVARI، SHAPOUR نويسنده , , Nasrolahi، Hamid نويسنده Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Javid، Sayed Ahmad نويسنده Dr. Javid Laboratory, Shiraz , , Hamedi، Sayed Hasan نويسنده Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, , , MOHAMMADIANPANAH، MOHAMMAD نويسنده , , Ansari، Mansour نويسنده Assistant Professor of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran , , AHMADLOO، NILOOFAR نويسنده , , MOSALAEI، AHMAD نويسنده ,
Abstract :
Introduction: Drug-induced vasculitis following chemotherapy has been rarely reported. We report such a case
of drug-induced vasculitis following chemotherapy in a breast cancer patient.
Report of the Case: A 52 year old woman with stage III breast cancer developed pathologically proven vasculitis
presenting as bilateral severe erythema, edema and ulceration on both feet 10 days following the 4th cycle of
adjuvant chemotherapy. Chemotherapy consisted of docetaxel, doxorubicin, and cyclophosphamide in each
cycle that was preceded by premedication including dexamethasone, granisetron, and H1 and H2 blockers.
Furthermore, filgrastim (5?g/kg) was administered following each cycle of chemotherapy during days 5-9. By
discontinuing chemotherapy and starting high-dose intravenous methylprednisolone, vasculitis was resolved.
The patient did not experience vasculitis following the re-challenge of chemotherapy excluding docetaxel and
filgrastim.
Conclusion: This case suggests that docetaxel and filgrastim might be added to the list of agents causing druginduced
vasculitis.
