Title of article :
Enthalpy of solution of terfenadine in ethanol/water mixtures
Author/Authors :
Jo?o Canotilho، نويسنده , , Felisbela S. Costa، نويسنده , , Adriano T Sousa، نويسنده , , J.Sim?es Redinha، نويسنده , , M.Lu??sa P Leit?o، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2000
Abstract :
The enthalpy of solution of terfenadine in ethanol/water mixtures, 0–20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1–2 kJ mol−1 in the enthalpy at a concentration value around 0.01 mol kg−1 is observed. This step in the enthalpy is interpreted as due to solute n-mer aggregates formation. The solubility of terfenadine in the cosolvent systems used in the calorimetric studies was determined.
Keywords :
Terfenadine , Solute self-aggregation , Crystallization , Crystal design , Solubility , Polymorphism , Solution enthalpy
Journal title :
Thermochimica Acta
Journal title :
Thermochimica Acta
