Thermo-physical examination: Synthesized 2-furano-4(3H)-quinazolinone and open quinazolinone (diamide) anticancer analogs with sodium dodecyl sulfate

In this study, the solution and self aggregation properties of sodium dodecyl sulfate (SDS) in presence of synthesized small molecules i.e. 3-(2-chloro benzylideneamine))-2-(furan-2-yl) quinazoline-4(3H) one (Q1) and N-(2-(p-tolyl carbamoyl) phenyl) furan-2-carboxamide (Q2) has been determined. The two compounds were earlier screened for anticancer activity from NCI, USA. In order to investigate the physico-chemical properties, simple and controlled methods were employed to obtain critical micellar concentration (CMC) values and thermo-acoustic parameters via conductance, compressibility coefficient (β), apparent molar volume (ϕv) and apparent molar adiabatic compressibility (ϕk) of SDS in the presence of Q1/Q2 at different temperatures (25, 30, and 35 °C). In addition, the effect of the addition of Q1/Q2 in SDS solution and to gain information regarding interaction between the molecules, FTIR and 1H NMR spectroscopic analysis was also carried out. The presence of different substitutions on the molecules affecting SDS behavior has also been discussed.