Alternative synthetic strategies for new drug candidates. The thermolysis reaction of N-(benzyl)-N′-(tert-butoxycarbonyl)sulfamide to yield benzylsulfamide

The hydrolysis of one sulfamide derivative under conventional conditions and under thermolysis reaction has been investigated. Comparison between these techniques revealed advantages in the use of thermal decomposition reaction to obtain sulfamides, due to the easy elimination of gaseous by-products produced in the reaction.