Title of article :
Targeting duplex DNA with DNA-PNA chimeras? Physico-chemical characterization of a triplex DNA-PNA/DNA/DNA
Author/Authors :
Petraccone، L. نويسنده , , Erra، E. نويسنده , , Messere، A. نويسنده , , Montesarchio، D. نويسنده , , Piccialli، G. نويسنده , , Napoli، L. De نويسنده , , Barone، G. نويسنده , , Giancola، C. نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Targeting double-stranded DNA with homopyrimidine PNAs results in strand displacement complexes PNA/DNA/PNA rather than PNA/DNA/DNA triplex structures. Not much is known about the binding properties of DNA-PNA chimeras. A 16-mer 5ʹ-DNA-3ʹ-p-(N)PNA(C) has been investigated for its ability to hybridize a complementary duplex DNA by DSC, CD, and molecular modeling studies. The obtained results showed the formation of a triplex structure having similar, if not slightly higher, stability compared to the same all-DNA complex.
Keywords :
DNA-PNA chimeras , triplex structure , circular dichroism , Molecular modeling , differential scanning calorimetry
Journal title :
BIOPOLYMERS (ORIGINAL RESEARCH ON BIOMOLECULES)
Journal title :
BIOPOLYMERS (ORIGINAL RESEARCH ON BIOMOLECULES)
