Title of article
Characterization of collagen-like heterotrimers: Implications for triple-helix stability
Author/Authors
Berisio، Rita نويسنده , , Granata، Vincenzo نويسنده , , Vitagliano، Luigi نويسنده , , Zagari، Adriana نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
-681
From page
682
To page
0
Abstract
This article deals with the effects of proline hydroxylation on collagen triple-helix stability, an issue that is still under discussion. To investigate the structural determinants of triple-helix stabilization by hydroxyproline (Hyp), we here characterized spectroscopically triple-helix heterotrimers containing both chains of (Pro-Pro-Gly)10 and (Pro-Hyp-Gly)10. Results are discussed in relation to the various triple-helix stabilization mechanisms.
Keywords
protein denaturation , hydroxyproline , Cd , polypeptide models , Collagen , heterotrimers , protein stability
Journal title
BIOPOLYMERS (ORIGINAL RESEARCH ON BIOMOLECULES)
Serial Year
2004
Journal title
BIOPOLYMERS (ORIGINAL RESEARCH ON BIOMOLECULES)
Record number
120717
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