Title of article :
Solid-phase synthesis of second-generation polyproline dendrimers
Author/Authors :
Albericio، Fernando نويسنده , , Giralt، Ernest نويسنده , , Sanclimens، Gloria نويسنده , , Crespo، Laia نويسنده , , Royo، Miriam نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Second-generation dendrimers have been prepared on solid phase by successive additions of branched polyproline building blocks starting from two different branching units anchored to the solid support. The preparation of Pro-rich building blocks was carried out by stepwise solid-phase synthesis and their iterative addition was performed by a convergent approach, also using solid-phase synthesis. cis-4-Amino-L-proline and imidazolidine-2-carboxylic acid were used as branching units due to their structural resemblance to proline. The optimized strategy allowed the target compounds to be obtained with high purities without the need for purification steps.
Keywords :
branched peptides , drug delivery , coupling reagents , Amino acid
Journal title :
BIOPOLYMERS (ORIGINAL RESEARCH ON BIOMOLECULES)
Journal title :
BIOPOLYMERS (ORIGINAL RESEARCH ON BIOMOLECULES)