Synthesis of a novel fluoroalkylated end-capped oligomer-bound antitumor segments and interaction of this oligomer with DNA

New water-soluble fluoroalkylated end-capped co-oligomer-bound antitumor agents such as 5-fluorouracil were prepared in good yields by the reaction of the corresponding isocyanate-blocked co-oligomers with the parent antitumor agents under mild conditions and fluoroalkylated end-capped co-oligomer-bound 5-fluorouracil could have a remarkably strong interaction with DNA.