Title of article
Synthesis and biological activity of medium molecular weight polymers of camptothecin
Author/Authors
Neung-Ju Lee، نويسنده , , Sung-Suk Ju، نويسنده , , Won-Jei Cho، نويسنده , , Seon-Hee Kim، نويسنده , , Kyung-Tae Kang، نويسنده , , Thomas Brady، نويسنده , , Emmanuel A. Theodorakis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
8
From page
367
To page
374
Abstract
A new monomer, 3,6-endo-methylene-1,2,3,6-tetrahydrophthalimidohexanoylcamptothecin (ETHCPT) was synthesized from 3,6-endo-methylene-1,2,3,6-tetrahydrophthalimidohexanoic acid. Its homopolymer and copolymer with acrylic acid (AA) were synthesized and spectroscopically characterized. The ETHCPT content in poly(ETHCPT-co-AA) obtained by elemental analysis was 37 wt.%. The number-average molecular weights of the polymers determined by gel permeation chromatography were as follows: Mn=9700 for poly(ETHCPT), Mn=25 500 for poly(ETHCPT-co-AA). The IC50 value of ETHCPT and its polymers against cancer cells was much larger than that of CPT. The in vivo antitumor activity of all polymers in Balb/C mice bearing the sarcoma 180 tumor cell line was greater than that of CPT at a dose of 100 mg/kg.
Keywords
photopolymerization , In vitro cytotoxicity , 3 , 6-Endo-methylene-1 , 2 , 6-tetrahydrophthalimidohaxanoylcamptothecin , 3 , camptothecin , Poly(ETHCPT-co-AA) , In vivo antitumor activity
Journal title
European Polymer Journal(EPJ)
Serial Year
2003
Journal title
European Polymer Journal(EPJ)
Record number
1211958
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