Phospholipid based polymer as drug release coating for cardiovascular device

A novel copolymer was synthesized by the radical polymerization of 2-methacryloyloxyethylphosphorylcholine, stearyl methacrylate, hydroxypropyl methacrylate and trimethoxysilylpropyl methacrylate. The polymer was characterized by Fourier transform infrared spectroscopy and proton nuclear magnetic resonance spectroscopy. The crosslinkable coating was prepared by dip-coating 5 mg/ml solution in tetrahydrofuran onto glass substrate. A stable crosslinked coating was obtained after curing the coating at 90 °C for 9 h. Contact angle results indicated the possible reorganization of the surface amphiphilic molecule that interpreted the excellent biocompatibility revealed by the results of the platelet adhesion and plasma recalcification time. Rhodamine S was used as a model drug to prepare drug-containing coating at the same conditions. Drug-releasing curves fall into Fickian release mechanism and there exists efficient releasing amount of the drug until 60 h.