Title of article
Synthesis and antioxidant evaluation of some novel ortho-hydroxypyridine-4-one iron chelators
Author/Authors
Mohammadpour، M. نويسنده Department of Medicinal Chemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. , , Sadeghi، A. نويسنده Department of Medicinal Chemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. ,
Issue Information
دوماهنامه با شماره پیاپی 0 سال 2012
Pages
9
From page
171
To page
179
Abstract
A series of ortho-hydroxypyridine-4-ones were prepared in high yields and evaluated for antioxidant and iron chelating activities. N1-H hydroxypyridinones Va, Vb, and Ve were the best radical scavengers in DPPH free radical scavenging assay. Compound Vb was proved to be the most potent compound in hydrogen peroxide scavenging assay. All of the synthesized compounds had very close chelating ability, compounds containing N1-CH3 hydroxypyridinone ring were stronger chelating agents.
Journal title
Research in Pharmaceutical Sciences
Serial Year
2012
Journal title
Research in Pharmaceutical Sciences
Record number
1216342
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