Author/Authors :
David Raj، C. نويسنده Department of Pharmacology and Toxicology, Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur -613402, Tamilnadu, India. , , Mohamed Shabi، M. نويسنده Department of Pharmacology and Toxicology, Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur -613402, Tamilnadu, India. , , Jipnomon، J. نويسنده Department of Pharmacology and Toxicology, Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur -613402, Tamilnadu, India. , , Dhevi، R. نويسنده Department of Pharmacology and Toxicology, Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur -613402, Tamilnadu, India. , , Gayathri، K. نويسنده Department of Pharmacology and Toxicology, Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur -613402, Tamilnadu, India. , , Subashini ، U. نويسنده Department of Pharmacology and Toxicology, Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur -613402, Tamilnadu, India. , , Victor Rajamanickam، G. نويسنده Department of Pharmacology and Toxicology, Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur -613402, Tamilnadu, India. ,
Abstract :
Standardization of induction of oxidative stress with Fenton mixture (FM) in isolated perfused rat kidney and the antioxidant effect of Terminalia arjuna bark in the isolated oxidatively stressed rat kidney has been evaluated. Six groups each containing eight isolated perfused rat kidneys were used for the present study and the oxidative stress was induced by perfusing the isolated kidneys with FM. The antioxidant effect of Terminalia arjuna at the dose of 250 and 500 mg/kg was evaluated in oxidative stress induced isolated kidneys. A significant (P < 0.05) increase in lipid peroxidation, gluatamate pyruvate transaminase, glutamate oxaloacetate transaminase were observed in oxidative stress induced isolated kidney. On perfusion with extract, the oxidative stress was decreased with increasing in antioxidants while the marker enzymes were found to maintain the normal level. It was concluded from the present study that hydroalcholic extract of Terminalia arjuna bark at the dose of 250 and 500 mg/kg showed significant antioxidant potential in isolated perfused rat kidneys.
