Author/Authors :
Jalali، M. نويسنده Food Security Research Center and School of Food Science Nutrition and, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. , , Mahdavi، M. نويسنده Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. , , Memarian، H.R. نويسنده , , Ranjbar، M. نويسنده Department of Chemistry, Faculty of Sciences, University of Isfahan, Isfahan, I.R. Iran. , , Soleymani، M. نويسنده Assistant Professor , , Fassih، A. نويسنده Department of Medicinal Chemistry and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan Univer , , Abedi، D. نويسنده Department of Pharmaceutical Biotechnology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfaha ,
Abstract :
The antimicrobial activity of thirty six novel dihydropyrimidine derivatives was evaluated against common pathogenic bacteria. Significant antimicrobial activity (MIC=32, 64 µg/ml) was observed. Escherichia coli and Pseudomonas aeruginosa as Gram-negative bacteria and Staphylococcus aureus as Gram-positive bacteria were determined to be the most susceptible pathogens in this study. The highest inhibitory activity was observed against Gram-negative microorganisms. The widest spectrum of antibacterial activity was exerted by C6 and C22. Most of the compounds had remarkable antifungal activity (MIC=32 µg/ml).
