Synthesis of novel star-like hyperbranched polymers with poly(amido amine) core and poly(l-lysine) shell

Hyperbranched poly(amido amine)s containing vinyl and hydroxyl groups were successfully synthesized via Michael addition polymerization of triacrylamide (TT) and 3-amino-1,2-propanediol (APD) with equal molar ratio in feed. 1H, 13C and HSQC NMR techniques were used to clarify the structure of hyperbranched polymers and polymerization mechanism. The Michael addition reaction of hyperbranched poly(1TT-1APD)s with primary amine-terminated poly(ε-benzyloxycarbonyl-l-lysine)s [PLys(Z)] yielded a star-like hyperbranched polymers with poly(1TT-1APD) core and Plys(Z) shell. The Z groups in PLys(Z) were removed under acidolysis, and thus star-like hyperbranched polymers with hydroxyl groups inside and primary amine groups outside were obtained successfully.