Author/Authors :
Shahraki، Touran نويسنده Department of Pediatrics, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran , , Rostami، Kamran نويسنده Department of Gastroenterology, Mid Staffordshire NHS Foundation Trust, Stafford , , Shahraki، Mansour نويسنده Department of Nutrition, and Research Center for Children and Adolescent Health, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan , , Bold، Justine نويسنده Institute of Health, Social Care and Psychology University of Worcester UK , , Danciu، Mihai نويسنده Department of Pathology, University of Medicine and Pharmacy Iasi, Romania , , Al Dulaimi، David نويسنده Department of Gastroenterology, Alexandra Hospital, Redditch , , Villanacci، Vincenzo نويسنده 2nd Department of Pathology, Spedali Civili University of Brescia Italy , , Bassotti، Gabrio نويسنده Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy ,
Abstract :
Aim: To assess the clinical characteristic of CD as well as correlation of symptoms and the degrees of intestinal mucosal lesions in Iranian children.
Background: Microscopic Enteritis (Marsh 0-II) is associated with malabsorption.
Patients and methods: From August 2005 to September 2009, 111 cases with malabsorption and classical gastrointestinal symptoms were evaluated.
Results: The mean (±SD) age of children with CD was 4.9±3.5 years (range, 6 month - 16 years) and the mean duration of symptoms was 8 ± 20.5 months. 50 cases (45%) were female and 61 cases (55%) were male. The most common clinical presentation was failure to thrive in 72%, chronic diarrhea in 65.8% and Iron deficiency anemia in 59.5%. Sensitivity of EMA was 100% in patients with Marsh IIIb and Marsh IIIc. EMA was also positive in 77% of cases with Marsh 0, 18% in Marsh I, 44% in Marsh II and 81.8% in patients with Marsh IIIa.
Conclusion: Histopathology did not reflect the severity of gluten sensitivity. This would suggest that the degree of intestinal mucosal damage might not be a reliable prognostic factor. Significant symptoms can be present with minor histological change on biopsy.
