Title of article :
Solution Structure of the BRK Domains from CHD7
Author/Authors :
Mark D. Allen، نويسنده , , Tomasz L. Religa، نويسنده , , Stefan M.V. Freund، نويسنده , , Mark Bycroft، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact ββαβ fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.
Keywords :
Chromatin , CTCF , CHD7 , CHARGE syndrome
Journal title :
Journal of Molecular Biology
Journal title :
Journal of Molecular Biology