Title of article
Structural Basis of TBX5–DNA Recognition: The T-Box Domain in Its DNA-Bound and -Unbound Form
Author/Authors
Christian U. Stirnimann، نويسنده , , Denis Ptchelkine، نويسنده , , Clemens Grimm، نويسنده , , Jonathan G. Seidman and Christoph W. Müller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
11
From page
71
To page
81
Abstract
TBX5, a member of the T-box transcription factor family, plays an important role in heart and limb development. More than 60 single point or deletion mutations of human TBX5 are associated with Holt–Oram syndrome that manifests itself as heart and limb malformations in 1 out of 100,000 live births. The majority of these mutations are located in the TBX5 T-box domain.
Keywords
Holt–Oram syndrome , TBX5 , protein–DNA interaction , crystal structure , DNA binding affinities
Journal title
Journal of Molecular Biology
Serial Year
2010
Journal title
Journal of Molecular Biology
Record number
1251860
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