Author/Authors :
Marco Retzlaff، نويسنده , , Julia Rohrberg، نويسنده , , Natascha Jennifer Küpper، نويسنده , , Stephan Lagleder، نويسنده , , Alexander Bepperling، نويسنده , , Florian Manzenrieder، نويسنده , , Jirka Peschek، نويسنده , , Kay-Eberhard Gottschalk and Horst Kessler، نويسنده , , Johannes Buchner and Helen R. Saibil، نويسنده ,
Abstract :
The tumor suppressor protein p53 is often referred to as the guardian of the genome. In the past, controversial findings have been presented for the role of the C-terminal regulatory domain (RD) of p53 as both a negative regulator and a positive regulator of p53 activity. However, the underlying mechanism remained enigmatic.
Keywords :
Tumor suppressor , phosphorylation , regulation of activity , quaternary structure , DNA binding
