The combinational effect of PP electret and monoolein on transdermal delivery of cyclosporine A in vitro

In this study, single and combined enhancing effect of polypropylene (PP) electret and 10% monoolein (Mono) on cyclosporine A (CsA) transdermal delivery were studied using improved Franz diffusion cell and high performance liquid chromatography (HPLC) technique. Single use of each PP electret or 10% Mono could enhance the transdermal delivery of CsA. +500 V or −500 V corona charged electret in combination with 10% Mono had the most significant enhancing effect. The PP electrets with the same corona voltage in absolute value had the similar enhancing effect on transdermal delivery of CsA when they were used in combination with Mono.