Author/Authors :
Nosratzehi، Tahereh نويسنده Department of Oral Medicine, Faculty of Dentistry, Zahedan University of Medical Science, Zahedan, Iran Nosratzehi, Tahereh , Arbabi-Kalati، Fateme نويسنده Department of Oral Medicine, Genetics of Non-Communicable Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran Arbabi-Kalati, Fateme , Salimi، Saeedeh نويسنده Department of Clinical Biochemistry, Cellular and Molecular Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Salimi, Saeedeh , Honarmand، Elham نويسنده Dentist, Zahedan University of Medical Sciences, Zahedan, Iran Honarmand, Elham
Abstract :
Background: Oral lichen planus (OLP) is a chronic immunological disorder with unknown etiology. The aim of this study was to determine psychological factors and salivary cortisol, IgA level in patients with oral lichen planus.
Materials and Methods: In this experimental study 20 patients with OLP and healthy person were admitted to this study. Saliva samples were collected between ?-?? Am. saliva cortisol, IgA level was detected by ELIZA method. In this study, patients with anxiety and depression were measured using the SCL-90 questionnaire. Data analyzed by t-test.
Results: The mean salivary cortisol level in patients with OLP was 3.2±1.9 ng/mL and the mean saliva cortisol level in healthy person was 3.5±1.9 ng/mL. Significant difference was observed in the salivary cortisol levels in the 2 study groups (p=0.04). The mean salivary IgA level in patients with OLP was 0.69±0.29 ng/mL and the mean saliva IgA level in healthy person was 0.9±0.43 ng/mL but no significant difference was observed in the salivary cortisol levels in the 2 study groups. Results showed that anxiety levels in patients with oral lichen planus were slightly higher than controls but there was no significant difference between healthy subjects.
Conclusion: Finding revealed the mean salivary cortisol level in patient with OLP less than healthy persons. Significant difference was observed in the salivary cortisol levels in the 2 study groups. Based on the t-student test, no significant difference was observed in the salivary IgA levels in the 2 study groups. Anxiety levels in patients with oral lichen planus were slightly higher than controls.
