Author/Authors :
Taghizade-Mortezaee، Fatemeh نويسنده Cellular and Molecular Research Center, Shahr-e-Kord University of Medical Sciences, Shahr-e-Kord, Iran Taghizade-Mortezaee, Fatemeh , Tabatabaiefar، Mohammad Amin نويسنده Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences,Isfahan, Iran , , Hashemzadeh Chaleshtori، Morteza نويسنده , , Miraj، Sepideh نويسنده Deparmment of Obstetrics and Gynecology, Hajar Hospital, Shahrekord University of Medical Sciences,Shahrekord, Iran ,
Abstract :
Uterine leiomyoma (UL) is the most common benign smooth muscle cell tumor with as yet unknown etiology and pathogenesis. This study was carried out to investigate the association of ESR1-351 A > G, ESR1 -397 T > C and CYP1A1 (Ile462Val) polymorphisms with UL in female patients of Iranian origin. In this case-control study, 276 patients with UL and 156 healthy women were recruited. The genetic polymorphisms ESR1-351 A > G, ESR1-397 T > C and CYP1A1 (Ile462Val) were genotyped by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). No significant difference were found in frequencies of both genotypes and alleles of ESR1-351 A > G, ESR1-397 T > C and CYP1A1 (Ile462Val) polymorphisms between the two groups (p > 0.05). Our findings indicated that these ESR1 and CYP1A1 polymorphisms were not associated with the development of UL in the cases reported here.
