A comparative physico-chemical study of bioactive glass and bone-derived hydroxyapatite

This study aimed at comparing the physico-chemical properties of bioactive glass and bone-derived hydroxyapatite (HA). 63S bioglass particles were obtained by sol–gel process and HA samples were derived from bovine bone. The chemical composition and the crystalline structure of both bioceramics were evaluated. Then the zeta potential in physiological saline and at different pH values was determined. It was found that the negativity of zeta potential for 63S bioglass is higher than that of bone-derived HA. The exothermal behavior through the hydration process was evaluated by isothermal microcalorimetry. The results showed that the librated heat during bioactive glass hydration process and its rate are almost ten times higher than HA. It could be related to different hydration mechanisms of bioglass and HA. However, for both bioglass and HA, this value is in the safe range and cannot be harmful for the adjacent tissues in the body.