Author/Authors :
O’Connor، Naphtali A. نويسنده Department of Chemistry, Lehman College City University of New York, 250 Bedford Park Blvd West, NY 10468, USA , , L?pez ، Gustavo E. نويسنده Department of Chemistry, Lehman College City University of New York, 250 Bedford Park Blvd West, NY 10468, USA , , Cruz، Anthony نويسنده Department of Chemistry, Lehman College City University of New York, 250 Bedford Park Blvd West, NY 10468, USA ,
Abstract :
A tautomeric equilibrium exists for quinoline-2-thiol and quinoline-2(1H)-thione. Quantum mechanical calculations predict the thione is the major tautomer and this is confirmed by the absorption spectra. The utility of quinolone-2-thiol/quinoline-2(1H)-thione as a chromophore for developing fluorescent sensors is explored. No fluorescence is observed when excited at absorption maxima, however a fluorescence increase is observed when exposed to HNO, a molecule of import as a cardiovascular therapeutic. Alkylated quinoline-2-thiol derivatives are found to be fluorescent and show a reduction in fluorescence when exposed to metals and changes in pH.
