Author/Authors :
Jafari، E. نويسنده , , Khodarahmi، GA نويسنده , , Hakimelahi، GH نويسنده , , Tsai، F.Y. نويسنده Center for General Education, Chang Gung University, Tao-Yuan 333, Taiwan. , , Hassanzadeh، F. نويسنده Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R.Iran. ,
Abstract :
Quinazolinones are interesting molecules with a wide range of biological activities. We prepared a number of quinazolinone derivatives by the condensation of 5-bromo- or 5-nitro-substituted anthranilic acids with chloro-acyl chlorides. Anthranilic acid derivatives were treated with either 3-chloro-propionyl chloride or 4-chloro-butyryl chloride to yield the corresponding N-acyl-anthranilic acids. The resultants were reacted with acetic anhydride to afford the benzoxazinone intermediates, which upon condensation with elected amines in either DMF or ethanol gave the corresponding tricyclic 4(3H)-quinazolinone derivatives. It was found that reactions in DMF produced higher yields.
