Histological analysis of bone repair in rat femur via nanostructured merwinite granules

There is a conspicuous need for in vivo evaluation of biomaterials prior to their application as bone graft or tissue engineering scaffold. Merwanite and HA in vivo application as bone filler would be studied in this study. Femoral injury was induced in male rats and early and late degrees in bone repair were evaluated. A histomorphological analysis of the bioceramics implants in rat femoral defect models suggested that both in early and late stage of bone repair, merwinite is more effective in promoting osteogenesis in comparison with HA and in late stage, the rate of new bone formation was faster in merwinite-filled-bone-defect than in HA models. The control groups showed limited osteogenesis. These results suggested that merwinite might be a potential and attractive bioceramic for bone replacement.