Antioxidant Activity of Artemisia Aucheri Sesquiterpene Lactone Extract

The liver is one essential organ in vertebrates and other animals levels serum albumin, LDH, ALP and AST is biomarkers of liver injury. Certain plants use in the treatment of liver. The aim of this study was to investigate the effect of Artemisia aucheri sesquiterpene lactone extract on liver. Therefore, the wistar rats were randomly divided into 6 groups that consisted of: A and B: extract treated (50 and 100 mg/kg), C: extract (50 mg/kg)+10% ethanol, D: extract (100 mg/kg)+10% ethanol, E: negative control (ethanol 10%) that received 10% ethanol, F: control group. Animals treated for 30 days every other day and 3 days after the last treatment the blood samples were collected and AST, ALP, LDH and serum albumin were assayed. The results showed that the mean serum albumin was not similar in all groups, and the highest and lowest mean serum albumin belong to the control group and negative control respectively (p < 0.05). Also significant differences in mean liver enzymes were observed in different groups (p < 0.05). Treatment groups showed increase of ALP in compared with the negative control group. We can conclude that sesquiterpene lactone compounds, particular parthenolides have most antioxidant properties.