Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects

Both EPA and DHA effectively reduced platelet aggregation at 24 h postsupplementation relative to placebo (−13.3%, P=.006 and −11.9%, P=.016, respectively), but only EPA reduced MP activity (−19.4%, P=.003). When grouped by gender, males showed a similar reduction in both platelet aggregation and MP activity (−20.5%, P=.008; −22%, P=.008) following EPA, while females showed significantly reduced platelet aggregation (−13.7%, P=.04) but not MP activity after DHA only.