Diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center: Development of a divergent strategy for the total synthesis of duocarmycins A and SA Original Research Article

The development of a divergent approach to the introduction of the C-ring of the duocarmycin A and SA alkylation subunits is detailed and includes the development of a diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center with control of its relative and natural R absolute configuration.